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Search Results for " romk inhibitor "

9

Compounds

Cat No. Product Name Synonyms Targets
T13320L VU591 Potassium Channel
1222810-74-3
T13320 VU591 hydrochloride Potassium Channel
VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50:0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentr...
T70634 Psycholeine
Psycholeine is isolated from the tropical plant Psychotria oleoides; exhibits somatostatin antagonistic activity on growth hormone secretion.
T23516 VU590 Potassium Channel
VU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1).VU590 inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling.
T62544 MK-8153
MK-8153 is a selective, potent, orally active inhibitor of extrarenal medullary potassium channels (ROMK), acting on ROMK EP (IC50: 5 μM) and hERG EP (IC50: 34 μM).MK-8153 can be used as a diuretic.
T12066 MK-7145 Others
MK-7145 is an inhibitor of ROMK(IC50 of 0.045 μM).
T24623 PF-06807656 PF 06807656
PF-06807656 is insensitive to the introduction of the N171D mutation in the ROMK conduction pore that greatly diminishes the activity of other small-molecule inhibitors. PF-06807656 is an effective ROMK inhibitor (Tl+ fl...
T70636 XAN35021
XAN35021, also known as ROMK inhibitor 25, or ROMK-IN-25, is a potent and selective ROMK inhibitor with improved pharmacokinetic properties. This product has no formal name at the moment. For the convenience of communic...
T62760 ROMK-IN-32
ROMK-IN-32 is an inhibitor of the extra-renal medullary potassium channel (ROMK) (IC50: 35 nM) and also inhibits hERG (IC50: 22 μM).
TargetMol